‘Gene Drive’ Mosquitoes Engineered to Fight Malaria

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By Heidi Ledford, Ewen Callaway and Nature magazine | November 24, 2015

Mutant mosquitoes engineered to resist the parasite that causes malaria could wipe out the disease in some regions—for good.

Humans contract malaria from mosquitoes that are infected by parasites from the genus Plasmodium. Previous work had shown that mosquitoes could be engineered to rebuff the parasite P. falciparum, but researchers lacked a way to ensure that the resistance genes would spread rapidly through a wild population.

In work published on November 23 in the Proceedings of the National Academy of Sciences, researchers used a controversial method called ‘gene drive’ to ensure that an engineered mosquito would pass on its new resistance genes to nearly all of its offspring—not just half, as would normally be the case.

The result: a gene that could spread through a wild population like wildfire.

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